| Insert |
DNA: genomic DESCRIPTION OF INSERT COMPONENT:
Genome: Homo sapiens
Gene symbol: ABL1
Other gene symbols: ABL
Genomic copy number: unique
Gene name: Abelson murine leukemia viral (v-abl) oncogene homolog 1
Contains complete coding sequence?: N
Chromosome: 9; Localization: 9 q34.1
Tissue: chronic myelogenous leukemia K-562 cell line
Type of DNA: genomic
Insert end: EcoRI
Insert end: EcoRI
Insert size (kb): 16.421
Cross references: DNA Seq. Acc.: U07562
Nucleotides 1-16321 of the insert correspond to
nucleotides 42692-59012 of U07562. Insert lengths(kb): 16.42099952697754 Tissue: chronic myelogenous leukemia K-562 cell line Gene product: Abelson murine leukemia viral (v-abl) oncogene homolog 1 [ABL] Alleles: D1, D2, D1, D2, A1, A2, B2, C1, C2, A1, A2, B1, B2, C1, C2, B1 |
| Comments |
Restriction digests of the clone give the following sizes (kb): BamHI--9.2, 6.4, 2.3, 2.1; BglI--7.2, 5.5, 2.5, 2.2, 1.3, 1.2; HindIII--11.5, 7.6, 0.82; PstI--5.1, 4.8, 3.75, 2.7, 2.1, 0.73, 0.64; EcoRI--7.0, 5.0, 2.65, 2.15, 1.1, 0.92, 0.38. The insert contains part of the intron between exon 1b and exon 1a. |
| References |
Grosveld G, et al. The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. Mol. Cell. Biol. 6: 607-609, 1986. PubMed: 3023859
Chissoe SL, et al. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics 27: 67-82, 1995. PubMed: 7665185
Bruce A Roe, personal communication
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